Exploring Astrocyte-Derived KYNA in Schizophrenia: Insights from a 3D Spheroid Model and Drug Screening Platform

Funda Orhan, Tian Sang, Xueqi Li, Marta Gomez, Sophie Erhardt

Department of Physiology and Pharmacology, Karolinska Institutet, Sweden

A New Pharmacological Treatment Concept for Alcohol Use Disorder: Combined Treatment With a Glycine Transporter-1-Inhibitor, Varenicline and Bupropion

Yasmin Olsson^1,2,3,3, Helga Lidö^1,2, Karin Ademar¹, Davide Cadeddu¹, Mia Ericson¹, Bo Söderpalm^1,2

¹Addiction Biology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden; ²Beroendekliniken, Sahlgrenska University Hospital, Gothenburg, Sweden; ³Department of Neurology, Sahlgrenska University Hospital, Sweden

Dysregulation of the kynurenine pathway is related to persistent cognitive impairments in TBE patients

Xueqi Li¹, Jacob Ahlberg Weidenfors¹, Vytautas Griška², Fredrik Piehl^3,4, Lars Lindquist⁵, Aukse Mickiene², Lilly Schwieler¹, Sophie Erhardt¹

¹Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden; ²Department of Infectious Disease, Lithuanian University of Health Sciences, 44 307 Kaunas, Lithuania; ³Unit of Neuroimmunology, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, 171 77 Stockholm, Sweden; ⁴Division of Neurology, Karolinska University Hospital, 171 76 Stockholm, Sweden; ⁵Department of Infectious Disease, Karolinska Institutet, 171 77 Stockholm, Sweden

Innovative CSF collection technique for rats: Understanding kynurenine pathway metabolite translation across brain, plasma and CSF

Varvara Louvrou, Marta Gómez Galán, Sophie Erhardt

Karolinska Institutet, Sweden

Neurophysiological signatures in the Basolateral Amygdala associated with an AUD-like phenotype in rat

Davide Cadeddu, Ana Domi, Erika Lucente, Louise Adermark

University of Gothenburg, Sweden

Integrative analysis multi-omics analysis of proteomics and metabolomics data of Karolinska Schizophrenia Project (KaSP)

Feride Ayten Eren¹, Humza Haroon², Sophie Erhardt¹, Doo-Sup Choi³

¹Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; ²Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; ³Department of Psychiatry and Psychology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA

Nicotine produces sex-specific neuroadaptations in the amygdala which in female rats can be reversed by physical activity

Erika Lucente, Ana Domi, Davide Cadeddu, Mia Ericson, Louise Adermark

University of Gothenburg, Sweden

Pharmacological treatment of the core symptoms of Anorexia nervosa – a systematic literature review

Elin Ingrid Munke, Jonas Eberhard, Erik Jedenius, Charalampos Vestakis

Region Skåne, Sweden

Polygenic Risk Score Analysis of Postpartum Psychosis and Cycloid Psychosis

Elin Hörbeck¹, Lina Jonsson¹, Carl Sellgren², Mikael Landén¹

¹Göteborgs Universitet, Sweden; ²Karolinska Institutet, Sweden

THE ACETYLCHOLINE ESTERASE INHIBITOR DONEPEZIL INCREASES ACCUMBAL DOPAMINE LEVELS AND BLOCKS THE ALCOHOL DEPRIVATION EFFECT IN RATS

Anna Loftén^1,3, Klara Danielsson¹, Louise Adermark², Mia Ericson¹, Bo Söderpalm^1,3

¹Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sweden; ²Department of Pharmacology, the Sahlgrenska Academy at University of Gothenburg, Sweden; ³Beroendekliniken, Sahlgrenska University Hospital, Sweden

The Pharmacological Effect of Acamprosate Originates from Different Drug Components

Karin Ademar¹, Anna Loftén^1,3, Mathilda Nilsson¹, Ana Domi^1,2, Louise Adermark^1,2, Bo Söderpalm^1,3, Mia Ericson¹

¹Addiction Biology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sweden; ²Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sweden; ³Beroendekliniken, Sahlgrenska University Hospital, Gothenburg, Sweden